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Reasons For Insufficient Tablet Hardness And Solutions

Jan 06, 2022

In the daily operation of the tablet press, we will inevitably encounter that the compressed tablets are not hard enough, which is a very distressing thing. Below we analyze the reasons and solutions that lead to the lack of hard compression.


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(1) Reason: The amount of binder or lubricant is small or inappropriate, resulting in uneven particle distribution, and layering of coarse and fine particles, which cannot be overcome even if the pressure is increased during tableting.
Solution: Use appropriate adhesives of tablet press machine and increase the dosage, improve the granulation process, mix the granules and other methods.
(2) Reason: The fineness of the medicine is not enough to be pulverized, and the fibrous, elastic medicine or oily ingredient content is high and the mixing is uneven.
Solution: The medicine can be crushed into smaller size, the adhesive with strong viscosity can be selected, the pressure of the tablet press can be increased, the oily drug absorbent can be added, and the methods can be mixed thoroughly.
(3) Reason: The water content is not suitable, too little water or the dry particles have large elasticity, because the drug containing crystal water loses more crystal water during the drying of the particles, it becomes brittle and easy to crack. However, if it is too large, the hardness will decrease.

Solution: The granulation process should control the water content according to different varieties. If the prepared granules are too dry, spray an appropriate amount of dilute ethanol (50%-60%), mix them, and then press the tablets.


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