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What Are The Problems That Are Prone To Occur In Capsule Filling

What Are The Problems That Are Prone To Occur In Capsule Filling

Oct 20, 2022
Variation in capsule load volume filled by capsule filling machines. The main reasons are capsule factors, drug factors, filling equipment factors and so on. If filling is required, the fluidity of the drug can be improved by adding appropriate excipients or granule preparation methods, and the filling equipment must be repaired and maintained in time to ensure its normal operation.

Hygroscopic. This is the most common problem in the preparation of capsule filling, because after absorbing water, the contents of the capsule will become soft and dense or even wet, and after absorbing water, the capsule will become soft and deformed, affecting the quality and efficacy of the drug. The solution is: on the one hand, strictly control the ambient temperature and humidity during the storage process of empty capsules, and process and fill the materials; on the other hand, improve the preparation process (such as granulation, waterproof coating, etc.) Wet packaging, such as glass bottles, aluminum-plastic packaging, etc.
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Insufficient content. Due to the occasional small loss during the filling process of the capsule filling machine, the final quantification may not be enough. You can prepare more powder particles before filling, and then remove the excess powder particles after filling, except for special materials.
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