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RQ-HMG-200 Wet Granulator
| Product Name | High Speed Wet Granulator Machine |
| Capacity | 5-320 kg/batch |
| Voltage | AC380v 3 phases 50Hz, can be Customized on demand |
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RQ-HMG-200 High Shear Wet Granulator: The Ultimate GMP-Compliant Wet Granulation Solution for Pharmaceutical & Nutraceutical Manufacturers
For European and American pharmaceutical and nutraceutical manufacturers, solid preparation production efficiency, granule quality consistency, and GMP regulatory compliance are the three non-negotiable core requirements. As the key front-end equipment for oral solid preparations, a high-performance wet granulator directly determines the flowability, compressibility, content uniformity, and final qualification rate of tablets, capsules, and granules. Traditional wet granulation equipment often suffers from low efficiency, uneven granules, difficult cleaning, poor sealing, and incompatibility with materials with large specific gravity differences—pain points that seriously restrict production efficiency and regulatory compliance.
Rich Packing, a professional pharmaceutical and packaging machinery manufacturer founded in 1993, has launched the RQ-HMG-200 Wet Granulator targeting the core demands of North American and European pharmaceutical and health product manufacturers. This high shear wet mixing granulator integrates advanced mechanical design, intelligent control systems, and GMP-compliant structural optimization, perfectly solving the industry’s long-standing pain points. It is widely used in the production of Western APIs, traditional Chinese medicine extracts, probiotic powders, protein powders, and other solid preparations, becoming the preferred wet granulation machine for standardized, large-scale production lines.
The Critical Role of a High-Performance Wet Granulator in Pharma & Nutraceutical Production
In the modern solid preparation production process, wet granulation is an irreplaceable core process. It mixes active pharmaceutical ingredients (APIs) and excipients uniformly, sprays a binder to form uniform wet granules, and solves the problems of poor powder flowability, dust flying, material delamination, and low content uniformity. For pharmaceutical and nutraceutical products, high-quality granules can:
1. Improve the stability of capsule filling and tableting, reducing the rejection rate caused by uneven feeding;
2. Reduce dust spillage, meet the contamination control requirements of GMP clean areas;
3. Enhance the content uniformity of preparations, especially for low-dose APIs and materials with large specific gravity differences between APIs and excipients;
4. Shorten subsequent drying and finishing time, reducing overall production energy consumption and labor costs.
A high-quality wet granulator is not just a production tool, but a core asset to ensure regulatory compliance, product stability, and long-term profitability. The RQ-HMG-200 Wet Granulator is tailored for this scenario, fully meeting the strict regulatory requirements of the EU GMP, US FDA cGMP, and ISO 14644-1 Class 8 clean area standards.
Introduction to RQ-HMG-200 Wet Mixing Granulator
The RQ-HMG-200 Wet Granulator is a fully automatic high shear wet granulation equipment independently developed by Rich Packing, designed for batch production in pharmaceutical and nutraceutical workshops. The machine adopts a vertical high-shear structure, integrating mixing, binder adding, granulation, and automatic cleaning in one step, with a compact structure, small floor space, and strong adaptability to workshop layout. All material-contact parts are made of SUS316L mirror-polished stainless steel, with no dead corners, easy disassembly, and fully compliant with cleaning validation requirements.
Unlike ordinary wet granulator machines on the market, the RQ-HMG-200 focuses on the production characteristics of European and American customers, optimizes the stirring, shearing, sealing, and control systems, and realizes high-efficiency, high-precision, and high-safety granulation production. It supports formula storage, parameter traceability, and automatic operation, and can be seamlessly connected to vacuum feeding, fluid bed drying, and finishing equipment to form a fully automated solid preparation production line.
Core Applications of RQ-HMG-200 Wet Granulation Machine in Pharmaceutical & Nutraceutical Industries
The RQ-HMG-200 Wet Granulator has a wide range of applications, covering all scenarios of wet granulation for solid preparations, and is especially suitable for European and American pharmaceutical companies, health product manufacturers, and CDMO production bases.
1. Pharmaceutical Industry Applications
• Western medicine: API granulation of antibiotics, vitamins, antihypertensive drugs, and other low-dose or high-potency products;
• Traditional Chinese medicine: granulation of water extracts, alcohol extracts, and soft extracts with strong viscosity and high hygroscopicity;
• Controlled/prepared preparations: granulation with strict requirements on particle size, bulk density, and uniformity.
2. Nutraceutical Industry Applications
• Probiotic powders, protein powders, dietary fiber, and collagen peptides with poor flowability;
• Solid beverages, meal replacements, and health granules with complex formulas;
• Powders with large specific gravity differences between main ingredients and excipients, which are difficult to granulate with traditional equipment.
The RQ-HMG-200 Wet Granulator can stably produce uniform granules with adjustable particle size (20–120 mesh) and bulk density, laying a solid foundation for subsequent capsule filling (such as Rich Packing NJP-1500D capsule filling machine), tableting, and packaging processes.
11 Exclusive Advantages of RQ-HMG-200 Wet Granulator (Optimized for GMP & Production Efficiency)
The core competitiveness of the RQ-HMG-200 Wet Granulator lies in its 11 targeted optimized designs, which fully solve the pain points of traditional equipment and meet the strict production and regulatory requirements of European and American customers.
1. Siemens PLC Intelligent Control System, Easy Operation & Process Traceability
The RQ-HMG-200 adopts a Siemens PLC microcomputer control system with a human-machine touch screen with strong interactivity. All key parameters—including stirring speed, chopping speed, temperature, mixing time, and binder dosage—can be directly set, adjusted, and called on the touch screen. The system supports multi-group formula storage, one-key calling for batch production, and avoids manual operation errors. It also meets the data traceability requirements of FDA 21 CFR Part 11 and EU GMP Annex 11, providing a strong guarantee for production verification.
2. Jacketed Pot Body for Precise Temperature Control
Equipped with pot bottom jacket technology, the RQ-HMG-200 realizes automatic temperature control of the cylinder with an accuracy of ±1℃. According to different process requirements, the machine can perform heat preservation or cooling on materials, which is especially suitable for heat-sensitive materials such as probiotics and vitamins. This design avoids material deterioration caused by temperature fluctuations and ensures the stability of active ingredients.
3. Horizontal & Vertical Dual-Chopping Structure for Higher Granulation Efficiency
On the basis of a horizontal chopper, the RQ-HMG-200 adds a set of vertical V-shaped choppers, forming a horizontal and vertical dual-cutting structure. This design accelerates material cutting speed, shortens granulation time by 30% compared with single-cutting equipment, and makes granules more uniform in particle size, with a one-time granulation rate of over 98%.
4. Soft Connection Design for Low Noise & Stable Power Output
The power part and the finishing screening part of the machine adopt soft connection, which greatly reduces power transmission attenuation and mechanical vibration. The operating noise is controlled below 65dB, meeting the noise requirements of GMP clean workshops, while extending the service life of core components and reducing daily maintenance costs.
5. Three-Leaf Butterfly Stirring Blade for Minimal Residue & Low Fine Powder Rate
The RQ-HMG-200 is equipped with a three-leaf butterfly stirring paddle with a small gap between the paddle and the pot body (less than 1.5mm). The paddle of RQ-HMG-200 can scrape off attachments on the inner wall during rotation, reducing powder deposition on the inner wall and bottom. The fine powder content of the finished granules is controlled below 8%, which greatly improves the utilization rate of materials and reduces production waste.
6. Automatic Cleaning Function to Eliminate Cleaning Dead Angles
To meet GMP cleaning validation requirements, the machine is designed with an automatic cleaning system, and the stirring paddle has an automatic lifting function. After granulation, the stirring paddle can be lowered to the pot bottom for thorough cleaning and then lifted to avoid dead angles. This design realizes CIP (Clean-in-Place) without disassembly, shortens batch conversion time by more than 50%, and reduces the risk of cross-contamination.
7. Binder Dripping Device for Timing & Quantitative Adding
The unique binder dripping device supports two adding methods: dripping or direct mixing, which can be adjusted according to different pharmaceutical formulas. The system realizes timing and quantitative addition of binder, reducing binder consumption by 20% compared with traditional equipment, while ensuring more uniform mixing and better granulation effect, especially for formulas with strict binder ratio requirements.
8. 3–5 Times Higher Efficiency Than Traditional Equipment
The RQ-HMG-200 integrates mixing and granulation in one step, with no need for secondary transfer. The particle size and bulk density can be freely adjusted according to production needs, and the overall efficiency is 3–5 times that of traditional swing granulators and ordinary wet mixers. It is especially suitable for powders with large specific gravity differences between APIs and excipients, solving the problem of difficult granulation of special formulas.
9. Dual-Sealing Technology to Protect Core Components & Extend Service Life
The connecting shafts of the core components (chopper and stirring paddle) adopt rubber ring oil seal + spiral air pressure dual-sealing technology, which completely solves the problems of material leakage, bearing damage, and transmission shaft failure caused by poor sealing. The shaft seal is designed as a pull-out type, which is convenient for disassembly, cleaning, and maintenance, reducing downtime caused by component replacement.
10. Full Perspective Operation & Dust-Free Production
The machine adopts a full-perspective observation design with a lighting observation window, allowing operators to monitor the granulation state at different stages in real time. It is reserved with a vacuum feeding port and equipped with a breathing valve, which effectively reduces dust spillage and realizes dust-free granulation production, fully meeting the contamination control requirements of GMP clean areas.
11. High-Safety Protection System for Operators & Equipment
The RQ-HMG-200 has a complete safety protection system: the pot cover is equipped with an interlock device, which will automatically alarm and stop when opened, and only run after the cover is closed. All electrical components comply with CE certification standards, with clear logic and stable performance, fully protecting the safety of operators and equipment.
How RQ-HMG-200 Wet Granulator Outperforms Traditional Wet Granulation Equipment
To help European and American customers clearly understand the advantages of the RQ-HMG-200 Wet Granulator, we have made a comprehensive comparison with traditional wet granulation equipment:
|
Index |
Traditional Wet Granulator |
RQ-HMG-200 Wet Granulator |
|
Production Efficiency |
Low, 1 batch/h |
High, 3–5 batches/h |
|
Granule Uniformity |
Uneven, high fine powder rate |
Uniform, fine powder <8% |
|
GMP Compliance |
Basic compliance, many dead angles |
Full compliance, no dead angles |
|
Cleaning Difficulty |
Dismantling required, long time |
Automatic cleaning, 50% time saved |
|
Binder Consumption |
Standard dosage |
20% less than standard |
|
Operating Noise |
>75dB |
<65dB |
|
Sealing Performance |
Single seal, easy to leak |
Dual seal, zero leakage |
|
Intelligent Degree |
Manual operation, no traceability |
PLC control, formula storage |
The data above fully proves that the RQ-HMG-200 Wet Granulator has obvious advantages in efficiency, quality, compliance, and cost control, and is the best upgrade choice for traditional production lines.
Why Rich Packing Is Your Trusted Partner for Wet Granulator Machine Supply
As a professional pharmaceutical and packaging machinery manufacturer with 28 years of experience, Rich Packing has served thousands of pharmaceutical and nutraceutical customers worldwide, and has a deep understanding of the regulatory requirements and production needs of European and American markets.
1. Strong R&D Strength: The technical team led by industry senior engineers has optimized the wet granulation process for more than 20 years, and all technologies have independent intellectual property rights;
2. Strict Quality Control: All products have passed CE, RoHS, EMC, and other international certifications, and comply with EU machinery directives and GMP design standards;
3. Complete Verification Documents: Provide IQ/OQ/PQ verification templates, material certificates, FAT/SAT test reports, etc., to assist customers in completing regulatory audits;
4. Global After-Sales Service: Set up a service center in the United States, provide on-site installation, commissioning, and training, and 7×24-hour remote technical support;
5. Customized Solutions: According to customer workshop layout, output requirements, and material characteristics, provide personalized wet granulation line solutions.
Rich Packing’s RQ-HMG-200 Wet Granulator has been widely recognized in the European and American markets, becoming a long-term partner of many well-known pharmaceutical and health product companies.
Conclusion
The RQ-HMG-200 High Shear Wet Granulator is a high-performance wet mixing granulator tailored for European and American pharmaceutical and nutraceutical manufacturers. With 11 core optimized designs, it solves the pain points of traditional equipment, improves production efficiency by 3–5 times, meets strict GMP/FDA regulatory requirements, and adapts to various difficult-to-granulate materials. As a key front-end equipment for solid preparation production, it can be seamlessly connected with capsule filling, tablet pressing, drying, and packaging equipment to build a fully automated, traceable, and contamination-free production line.
Rich Packing, with complete international certifications, and global after-sales service, provides you with reliable equipment and professional technical support. The RQ-HMG-200 Wet Granulator for Powder will help you improve product quality, reduce production costs, and enhance market competitiveness.
FAQ About RQ-HMG-200 High Shear Wet Granulation Equipment
1. Is the RQ-HMG-200 Wet Granulator compliant with EU cGMP and US FDA standards?
Yes, it fully complies with EU GMP, US FDA cGMP, and CE certification requirements, supporting IQ/OQ/PQ validation.
2. What is the batch capacity of the RQ-HMG-200 Wet Granulator?
The standard batch capacity is 50–200kg per batch, adjustable according to customer needs.
3. Can it handle materials with large specific gravity differences between APIs and excipients?
Yes, its high-shear mixing and dual-chopping structure are specially optimized for such materials, ensuring uniform granulation.
4. How much time does it take to clean the machine between different batches?
With automatic cleaning and lifting stirring paddle, batch cleaning takes only 15–20 minutes, no disassembly required.
5. Does the machine support formula storage and data traceability?
Yes, Siemens PLC supports multi-group formula storage and parameter recording, meeting data integrity requirements.
6. What is the operating noise level?
The noise is controlled below 65dB, suitable for GMP clean workshops.
7. Is the sealing system maintenance-friendly?
The dual-sealing structure is pull-out designed, easy to disassemble and replace, with a service life of more than 2 years.
8. Can it be connected to a vacuum feeding system?
Yes, it is reserved with a vacuum feeding port for dust-free automatic feeding.
IPv6 network supported